Prevention and treatment coverage have substantially improved for major infectious diseases, maternal, neonatal and child health care, leading to steady decline in incidence and mortality from these diseases in the past two decades. However, the current rate of change is insufficient to reach the 2030 SDG targets. Preserving progress made, constant vigilance, early detection and monitoring, a unified national response (in coordination with global partners) and, rapidly scaling up solutions for high risk, resource limited and marginalized populations are key to achieve SDGs.